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ABSTRACT:
A clinical study was undertaken to ascertain antioxidant nature
of homoeopathic medicine, which yielded promising results.
Modern medical research has been quoted as evidence in their
support. Free radicals are notorious substance produced in the
cell, which damages normal healthy cells, causing cellular
dysfunction and cellular death. Thus free radicals lay the
foundation of sickness (miasm) and antioxidants erases the miasm.
Anti0xidants are now widely accepted as antichronic disease as
well as antiageing factor. This study aims to open the treasure
of homoeopathic antioxidants for more detailed research.
INTRODUCTION:
The recognition of organic free radicals by Gomberg in 1900
and subsequent development in the realm of free radicals has
substantial y contributed to medical science, for the whole new
concept which indicates a possible contributing cause for
chronic disease and its chronicity. T.F.slater one of the
pioneer in this field suggested significant tissue injury in
disease is brought about by free radicals. (i)
Free radicals are chemical species possessing unpaired electron
that can be considered as fragments of molecules and which are
generally very reactive. They are continuously produced in the
cell as by products of cellular metabolism, either accidentally
or deliberately. (2)
When free radicals
are present in large numbers, they go on a rampage and damage
normal healthy cells, laying the foundation of sickness. (Psora,
syphilis, sycosis.) The presence of excessive amount of free a
radical is called " oxidative stress ". Oxygen is the most
important source of Free radicals although most of the oxygen is
excreted as Co2 other sources of Free Radicals include
environment al pollutants, cigarette smoke, UV rays, drugs,
pesticides etc.
Free radicals can
disturb biological systems by damaging their major constituent
molecules -lipids (polysaturated fatty acids). Proteins,
carbohydrates and DNA. Free radicals attack the Polyunsaturated
Fatty acids (PUFAS) present within the cell membrane and
low-density lipoprotein (LDL) particles. This is known as lipid
oxidation (lipid peroxidation) as a result the structural
integrity of the cell membrane is lost. Which, ultimately leads
to cell injury and cell death. (fig.no.1) Similarly free
radicals also damage the DNA present in the nucleus of the cell.
Daily the DNA of each cell is attacked by free radicals about
10,000 times! This can leap to mutagenesis and carcinogenesis. .
But to defend these injuries, cells are in possession of enzymes
and compounds to scavenge these free radicals known as
antioxidants. Antioxidants prevent damage induced by free
radicals and play a very crucial role in preventing or delaying
the onset of disease. Possibly in chronic disease homoeopathic
medicine enhances the scavengers (antioxidants) to minlmise the
cellular injury brought about by free radicals in pathogenesis
of vast number of pathological conditions like atherosclerosis
(4), cataract, ageing (3), cerebro & cardiovascular disorders
(4), Diabetes Mellitus (5), hepatocellular injury (6), skin
disease, carcinoma (26). Etc.
A more detailed
discussion of free radical biochemistry can be found in several
excellent book on the subject.(7-10). There are a number of
homoeopathic medicines where the active constituents of the
medicine are scavengers (Antioxidant substances shown elsewhere
in this paper). Many a homoeopathic medicine has flavones(11) as
their constituent (crategeus, chelidonium, avena sativa)
flavones are coined as antioxidants but the true nature and
specific flavones are yet to be established.
Antioxidants
(Only a few important antioxidants are mentioned here)
|
|
No. |
Antioxidant |
Antioxidant Nature
|
|
01. |
Carotene
(constituent of Calendula & Capsicum) |
Protection against
v Carcinoma lung, cervix
v Cardiovascular diseases |
|
02. |
Ascorbic acid
(constituent of Capsicum) |
Ascorbic acid (constituent of capsicum) An ideal electron
donor reducing superoxide,
Hydroxyl radicals, Hypochlorus acid & other reactive
oxidants from activated Micro /
Macrophages.
v Anti atherosclerosis.
v Plmonary antioxidant defence against smoking etc. |
|
03. |
Copper
(Cuprum metallicum) |
v
Essential constituent of superoxide dismutase. (a potent
antioxidant enzyme)
vMajor component of caeroloplasmin (Antioxidant)
|
|
04. |
Zinc
(Zincum metallicum)
|
Essential component of
superoxide dismutase |
|
05. |
Selenium
(Also constituent of Agaricus muscarius) |
v
Essential constituent of glutathione peroxide. First line
antiperoxidatonn defense. |
|
06. |
Silymarin
& Silybin
(constituent of Carduus)
|
Inhibits lipid peroxidation |
|
07. |
Lycopin
(constituent of calendula off.)
|
v
Systemic antioxidant. |
METHOD & MATERIAL:
In Nambison' s
Homoeo chamber 35 Patients (12 acute & 23 Chronic in nature)
were selected to be treated with Homoeopathic Antioxidants Some
knowingly & some unknowingly.
Local antioxidant:
Local antioxidant was directed to be applied on the affected
part after thorough washing of the part with water, and then
medicine was to be painted 2-3 Times a day.
Systemic antioxidant:
Systemic
antioxidant was directed to be taken 15-20 drops in half cup of
Luke Warm water 3 times a day. (Dose was titrated according to
the prevailing Condition.)
Thorough surfing of homoeopathic
literature was done to find out their active constituents and
antioxidant nature, and then they were applied on sick due to
their antioxidant nature and on some red line Indication.
Pre and post therapeutic
evaluation was done on the clinical improvement and in some
cases pathological investigations were done to ascertain
improvement
|
Homoeopathic medicine their Antioxidant constituents &
Nature.
(11) |
|
No. |
Medicine |
Antioxidant constituent |
Antioxidant nature |
|
01. |
Agaricus muscarius |
Selenium |
Cerebro-vascular
Antioxidant |
|
02. |
Calendula off |
Carotene, Lycopin
(2) |
Local
& systemic Antioxidant |
|
03. |
Carduus mar |
Silymarin (23)
Silybin (24) |
Hepatic Antioxidant |
|
04. |
Capsicum |
Ascorbic acid, Carotinoids |
Systemic & local Antioxidant |
|
05. |
Fucus ves. |
Carotene |
Systemic Antioxidant |
|
06. |
Cuprum met. |
Cu
(Element) |
Cerebro-vascular
Antioxidant |
|
07. |
Selenium |
Se
(Element) |
Cerebro-vascular
Antioxidant |
|
08. |
Zincum met. |
Zn
(Element) |
Cerebro-vascular
Antioxidant |
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