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ANTIOXIDANTS IN HOMEOPATHY
 A Revolutionary Concept, Evidence & its  Therapeutic potential.
Dr.K.M.Nishanth D.H.M.S.B.H.M.S (Gold medal).
Email : dr_nisanth@yahoo.com 
 

 

ABSTRACT: 
A clinical study was undertaken to ascertain antioxidant nature of homoeopathic medicine, which yielded promising results. Modern medical research has been quoted as evidence in their support. Free radicals are notorious substance produced in the cell, which damages normal healthy cells, causing cellular dysfunction and cellular death. Thus free radicals lay the foundation of sickness (miasm) and antioxidants erases the miasm. Anti0xidants are now widely accepted as antichronic disease as well as antiageing factor. This study aims to open the treasure of homoeopathic antioxidants for more detailed research. 

INTRODUCTION:
The recognition of organic free radicals by Gomberg in 1900 and subsequent development in the realm of free radicals has substantial y contributed to medical science, for the whole new concept which indicates a possible contributing cause for chronic disease and its chronicity. T.F.slater one of the pioneer in this field suggested significant tissue injury in disease is brought about by free radicals. (i)
Free radicals are chemical species possessing unpaired electron that can be considered as fragments of molecules and which are generally very reactive. They are continuously produced in the cell as by products of cellular metabolism, either accidentally or deliberately. (2)

When free radicals are present in large numbers, they go on a rampage and damage normal healthy cells, laying the foundation of sickness. (Psora, syphilis, sycosis.) The presence of excessive amount of free a radical is called " oxidative stress ". Oxygen is the most important source of Free radicals although most of the oxygen is excreted as Co2 other sources of Free Radicals include environment al pollutants, cigarette smoke, UV rays, drugs, pesticides etc.

Free radicals can disturb biological systems by damaging their major constituent molecules -lipids (polysaturated fatty acids). Proteins, carbohydrates and DNA. Free radicals attack the Polyunsaturated Fatty acids (PUFAS) present within the cell membrane and low-density lipoprotein (LDL) particles. This is known as lipid oxidation (lipid peroxidation) as a result the structural integrity of the cell membrane is lost. Which, ultimately leads to cell injury and cell death. (fig.no.1) Similarly free radicals also damage the DNA present in the nucleus of the cell. Daily the DNA of each cell is attacked by free radicals about 10,000 times! This can leap to mutagenesis and carcinogenesis. . But to defend these injuries, cells are in possession of enzymes and compounds to scavenge these free radicals known as antioxidants. Antioxidants prevent damage induced by free radicals and play a very crucial role in preventing or delaying the onset of disease. Possibly in chronic disease homoeopathic medicine enhances the scavengers (antioxidants) to minlmise the cellular injury brought about by free radicals in pathogenesis of vast number of pathological conditions like atherosclerosis (4), cataract, ageing (3), cerebro & cardiovascular disorders (4), Diabetes Mellitus (5), hepatocellular injury (6), skin disease, carcinoma (26). Etc.

A more detailed discussion of free radical biochemistry can be found in several excellent book on the subject.(7-10). There are a number of homoeopathic medicines where the active constituents of the medicine are scavengers (Antioxidant substances shown elsewhere in this paper). Many a homoeopathic medicine has flavones(11) as their constituent (crategeus, chelidonium, avena sativa) flavones are coined as antioxidants but the true nature and specific flavones are yet to be established. 

Antioxidants (Only a few important antioxidants are mentioned here)

No.

Antioxidant

Antioxidant Nature

01.

Carotene (constituent of Calendula & Capsicum)

Protection against
v     Carcinoma lung, cervix
v     Cardiovascular diseases

02.

Ascorbic acid (constituent of Capsicum)

Ascorbic acid (constituent of capsicum) An ideal electron donor reducing superoxide,
Hydroxyl radicals, Hypochlorus acid & other reactive oxidants from activated Micro /
Macrophages.
v Anti atherosclerosis.
v Plmonary antioxidant defence against smoking etc.

03.

Copper (Cuprum metallicum)

v   Essential constituent of superoxide dismutase. (a potent antioxidant enzyme)
vMajor component of caeroloplasmin (Antioxidant)
 

04.

 Zinc (Zincum metallicum)

 

Essential component of superoxide dismutase

05.

Selenium (Also constituent of Agaricus muscarius)

v     Essential constituent of glutathione peroxide. First line antiperoxidatonn defense. 

06.

 Silymarin & Silybin (constituent of Carduus)

 

  Inhibits lipid peroxidation

07.

 Lycopin (constituent of calendula off.)

 

v     Systemic antioxidant.

METHOD & MATERIAL:

In Nambison' s Homoeo chamber 35 Patients (12 acute & 23 Chronic in nature) were selected to be treated with Homoeopathic Antioxidants Some knowingly & some unknowingly.

Local antioxidant: Local antioxidant was directed to be applied on the affected part after thorough washing of the part with water, and then medicine was to be painted 2-3 Times a day.

Systemic antioxidant:

Systemic antioxidant was directed to be taken 15-20 drops in half cup of Luke Warm water 3 times a day. (Dose was titrated according to the prevailing Condition.)

Thorough surfing of homoeopathic literature was done to find out their active constituents and antioxidant nature, and then they were applied on sick due to their antioxidant nature and on some red line Indication.

Pre and post therapeutic evaluation was done on the clinical improvement and in some cases pathological investigations were done to ascertain improvement 

Homoeopathic medicine their Antioxidant constituents & Nature. (11)

No.

Medicine

Antioxidant constituent

Antioxidant nature

01.

Agaricus muscarius

Selenium

Cerebro-vascular Antioxidant

02.

Calendula off

Carotene, Lycopin (2)

Local & systemic Antioxidant

03.

Carduus mar

Silymarin (23) Silybin (24)

Hepatic Antioxidant

04.

Capsicum

Ascorbic acid, Carotinoids

Systemic & local Antioxidant

05.

Fucus ves.

Carotene

Systemic Antioxidant

06.

Cuprum met.

Cu (Element)

Cerebro-vascular Antioxidant

07.

Selenium

Se (Element)

Cerebro-vascular Antioxidant

08.

Zincum met.

Zn (Element)

Cerebro-vascular Antioxidant

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