Drug Proving
Drug proving in aphorism – 105-144
Human experiments before Hahnemann - mentioned by Albrecht Von Haller
Experimented by Stork (1750-60) / Alexander (1768)
Dose in proving aph 128- 4-6 small globules of 30th on empty stomach daily, for several days, till alteration of health is conspicuous
Observations on sick can be included - aph 142
Hyganthropharmacology – Human provings (James Stephenson)

Source books
Fragmenta de viribus medicamentorum positivus sive in sano corpore humano observatis ( Latin) = Fragments on the Positive Powers of Drugs, - that is to say, their effects observed in the healthy body
Published 1805, 27 drugs (24 carried forward)

Reine arzneimittellehre (German) = Materia Medica Pura (Latin), 6 volumes
First edition 6 vols – 1811 – 1821 ( Vol I in 1811 = 12 drugs)
Present edition – Third ed. of Vol I & II (1830 –1833), and second ed. of vol III – VI (1825 – 1827)
Translated by RE Dudgeon Annotation by R Hughes
Total no. of drugs - 67 Fellow provers – 37
Hahnemann's symptom - No name or sign attached
Doubtful symptoms in brackets
Mental symptoms from Langhammer suspect
Dose - Tincture / Ist trituration to 30th in III ed.

Die Chronischen Krankheiten (German) = Chronic Diseases
First ed. Vol I – III 1828, Vol IV 1830 Second ed. Vol I – V 1835-39
Translation - Prof Louis H Tafel Annotation - Dr. R Hughes
No of drugs = 47 (30 not in MMP)
Nenning's symptoms – Hahnemann questioned, Hering clarified later as trustworthy.
Dose – First ed 2nd to 12th Second ed – 6th to 30th

The Encyclopedia of Pure Materia Medica - TF Allen
Vol 10 + 2 (index = "Symptom register") Year - 1874
Total - 1039 drugs
Other books by TF Allen - Hand book of Materia Medica and Homoeopathic Therapeutics, A Primer of Materia Medica

The Guiding Symptoms of our Materia Medica - C Hering
Vol 10 year 1879 - 1891 Hering died after completing part of Vol III
Total No. of drugs - 410 Each described under 48 sub sections
5 grades - occasionally confirmed (ı), Frequently confirmed (ıı), Verified by cures (ıı), Repeatedly verified (ıı) and approved characteristic (☞)
Other notations - f (Pathological / physiological condition), Three vertical dots (Observations from old /new school), π (observed only on sick, while under medicinal action) and "t" (toxicological)
Other books by Hering – Condensed Materia Medica, Homoeopathic Domestic Physician

Cyclopedia of Drug Pathogenesy - R Hughes & JP Dake
Vols - 4 Year - 1886 - 1891
Proving Symptoms not in schema, but narrative, in order of occurrence (“Materia medica starts with vertigo and ends with confusion” – Hughes)
Animal experiments & poisonings included
Discards provings less than two people, observations in sick and potencies above 12th unless corroborated by lower potencies

Other Materia Medicae
Key Notes
Keynotes and Characteristics with Comparisons – Allen HC
Keynotes of The Materia Medica - Guernsey H. N
Keynotes of The Homoeopathic Materia Medica – A Von Lippe
Keynotes And Red Line Symptoms of The Materia Medica - A Von Lippe
A Synoptic key of the Materia Medica – Boger CM

Comparative Materia Medica
Comparative Materia Medica - RH Gross
Comparative Materia Medica - EA Farrington
The Study Of Remedies By Comparison – HA Roberts

Clinical Materia Medica
Clinical Materia Medica - Farrington E. A.
Pocket Manual of Homeopathic Materia Medica – Boericke W
A Manual of Materia Medica Therapeutics and Pharmacology - Blackwood AL
Physiological Materia Medica – WH Burt
Text Book of Materia Medica with Therapeutics - Cowperthwait
Materia Medica of Homoeopathic Medicines – Phatak

Descriptive Materia Medica
Lectures on Homoeopathic Materia Medica – Kent JT
Homoeopathic Drug Pictures - ML Tyler
A study on Materia Medica - NM Choudhuri
A dictionary of Practical Materia Medica (3 vols) - JH clarke year - 1900
A Manual of Homoeopathic Therapeutics - EA Neatby & TG Stonham
Lectures on Materia Medica – Dunham C
Plain Talks on Materia Medica with Comparisons - WI Pierce

Minerals
Text book of Homoeoapthic Materia Medica - Otto Leeser

Nosodes
The Materia Medica of Some Important Nosodes - Allen HC
Materia Medica of Nosodes – OA Julian

Other
New old and forgotten Remedies – Anschultz EP

Provers / Authorities
Hahnemann
Total Provings published by Hahnemann - 67 (MMP) + 30 (CD) + 3 (Fragmenta) = 100 (99 according to Hughes)

Acon, Alum, Am-c, Arg-m, Arn, Ars, Aur, Bar-c, Bell, Bism, Borx, Bry, Calc, Camph, Cann-s, Canth, Caps, Carb-v, Carb-ac, Caust, Cham, Chel, Cic, Cina, Chin, Clem, Cocc, Coff, Coloc, Con, Cupr, Cycl, Dig, Dros, Dulc, Eup-per, Euph, Ferr, Graph, Hell, Hep, Hyos, Ign, Iod, Ip, Kali-c, Led, Lyc, Mag-c, Mag-m, Meny, Mag-p, Merc, Mosch, Mur-ac, Nat-c, Nat-m, Nit-ac, Nux-v, Op, Petr, Ph-ac, Phos, Puls, Rheum, Rhus-t, Ruta, Sabad, Samb, Sars, Sep, Sil, Spig, Spong, Stann, Staph, Stram, Sulph, Thuj, Valer, Verat

Hering
All-c, Brom, Calc-ar, Calc-p, Calc-s, Fl-ac, Glon, Ham, Hyper, Kalmia, Lach, Lith-c, Lyss, Meph, Psor, Sel, Ther

Stapf
Anac, Ant-t, Colch, Croc, Mez, Plat, Sabin

Burt
Caul, Coll, Dios, Erig, Ust, Verat-v

Swan
Lac-c, Lac-d, Med, Syph

Nenning
Aeth, Am-m, Mill

Petroz
Actea-sp, Murex, Aster

Burnett
Bacill, Bellis-p, Urtica

HC Allen
Kali-p, Sec, Viburnum

TF Allen
Amyl-nit, Pic-ac

Drysdale - Kali-bi, Pyrog Nunez - Tarent Russel & Stokes – Naja
Rubini - Cactus Caspari - Ant-c Farrington - Nat-p Clotar Muller - Coca Dr. Ray (Calcutta) - Blatta-o Clarke - Rad-br DM Foubister - Carc
Mure – Elaps cor, Bufo

Common Names of Remedies (other than from “Key notes”)
Abies-c - Hemlock spruce
Abies-n - Black spruce
Absinth - Common worm wood
Acalypha - Indian Nettle
Actea-sp - Baneberry
Adonis - Pheasant's eye
Art-v - Mug wort
Asaf - Gum of the stinkasand
Aven-sat - Common oat
Bellis-p - Daisy
Clematis - Virgin's Bower
Convallaria - Lily of the Valley
Crataegus - Hawthorn berries
Echinacea - Purple cone-flower
Erigeron - Flea Bean
Grindelia - Rosinwood
Hydrocotyle - Indian Pennywort
Mancinella - Hippomane
Mercurialis Perennis - Dog's Mercury
Ornithogalum - Star of Bethlehem
Piper Methysticum - Kava Kava
Raphanus - Black garden Radish
Sabal ser - Saw palmetto
senega - Snake wort
Squilla - Sea onion
Thiosinaminum - Rhodallin
Scirrhinum - Carcinominum
Teucrium - Cat thyme
Alumen – Potash alum
Calc-s - Plaster of Paris
Eup-per - Thoroughwort
Mez - Spurge Olive
Nat-s - Glauber's salt
Ox-ac - Sorrel acid
Pyrog - Artificial Sepsin
Ratanhia - Krameria Triandra, Mapato
Ruta - Bitterwort
Sabadilla - Asagraea Officinalis, Veratrum Officinalis
Sars - Smilax
Symphytum - Knitbone, Boneset
Oleum Petrae - Petroleum
Puls - Anemone pratensis
Syph - Leusinum, Leuticum
Med - Glinicum
Abrotanum - Artemisia abrotanum
Cina - Artemisia maritima
Kurchi - Holerrhena Antidysenterica./ Wrightia tinctoria

Trio’s
Trio of climacteric remedies – Lach-Sep-Sulph
Trio of pleurisy – Acon-Bry-Sulph (Nash)
Trio of offensiveness – Merc-Kreos-Bapt (Nash)
Trio of Weakness – Ars- Mur-ac-Carb-v (Nash)
Trio of Spasmodic cough – Dros-Ip-Cupr (Nash)
Trio of Ptosis – Sep-Caust-Gels (Nash)
Trio for condylomata – Thuj-Staph-Nit-ac(Nash)
Three remedies for the treatment of chronic rheumatism and paralysis - Caust, Rhus-t, Sulph (Nash)

Caution
Apis - Lower potency repetition in pregnancy (Farrington)
Kali-c - too high in old gout, bright's disease, advanced phthisis (Kent)
Merc - too often in psoric cases (Kent)
Ars - in dysentery (Kent)
Sulph - Phthisis and structural diseases (Kent)
Phos - Beware in impotency or very weak constitutions (Kent)
Caution in Tub - When skin and intestines do not work properly (Boericke)
Caution in Tub for children and seniles - Should not be given without most careful cardiac examination (Boericke)
Cannot often be repeated in chronic cases without an intercurrent called for by the symptoms - Nat-m
Should never be given during fever paroxysm - Nat-m
Do not give when there is fever or constipation - Santonine
Should not be given in lying-in period except in high potencies (Hering) - Iod
Should never be given in syphilis - Ferr
Never use potash salts when there is fever (TF Allen)

Relationship of Remedies
Relationship of remedies with similar action but dissimilar in origin are called - Concordant (Farrington)
Relationship of remedies with similar action, similar origin - Family relationship
Relationship where when one group of symptoms are removed by a remedy symptoms of it's related remedy appear – Cognate (eg- Sulph-Calc-Lyc, Caust-Coloc etc)
Remedies which have the same form / appearance but different in origin are called - Isomorphic (Bism - Ant-c, Phos, Ars – Clarke)

Remedies in series
Sulph – Calc – Lyc (Wright)
Sulph – Sars – Sep (Wright)
Ign - Nat-m – Sep (Wright)
Puls - Sil - Fl-ac (Wright)
Ars - Thuj – Tarent (Wright)
All-c - Phos – Sulph (Wright)
Merc - Hep - Sil (Kent)
Sulph - Ars - Sulph (Kent)
Arn - Rhus-t - Calc (Kent)
Puls - Sil - Kali-s (Kent)

Veg / Chemical Analogues
Cupr veg analogue - Ip
Cham chemical analogue - Mag-p
Dulc chemical analogue - Kali-s
Ferr veg analog - Chin
Merc veg analog - Mez
Phos veg analog - All-c
Plat veg analog - Valer
Plb veg analog - Podo
Kali-i veg analog - Phyt

After Arn in injury when pricking and soreness of periosteum remains - Symph
In scrofulosis when the best selected remedy fails to relieve - Ther
Thuj complementary - Med, Sabin, Sil ( Nat-s, Ars – Boericke)
Chronic of Ars in Asthma - Thuj (Kent)
Trill-p complementary in haemorrhagic affections - Calc-p
Tub complementary - Psor, Sulph (Calc, Chin, Bry - Boericke
After Rhus-t in rheumatism - Tub (Kent)
When Psor, Sulph or the best-selected remedy fails - Tub
After Tub fails - Syph (Boericke)
Remedy when vaccinosis blocks action of Tub - Thuj (Boericke)
Follows Psor as a constitutional remedy for Hay fever, Asthma - Tub
Coloc complementary in dysentery - Merc
Con is followed well by this remedy in tumor of mammae - Psor
Psor followed by this remedy in mammary cancer - Sulph
This remedy precedes and follows Calc well in Calc subjects who have scanty menses - Con (Clarke)
Croc followed by - Nux, Puls, Sulph
Dros complementary - Nux-v
Dros followed by - Calc, Puls and Sulph
Dulc complementary - Bar-c
Dulc incompatible - Bell, Lach, Acet-ac
Bell incompatible - Acet-ac (Boericke)

Borax incompatible - Acet-ac
Eup-per followed by - Nat-m and Sep
Ferr complementary - Alum, Chin (Ham – Boericke)
Ham complementary in hemorrhage - Ferr
Chin complementary - Ferr, (Calc-p – Boericke)
Chin incompatible after - Dig, Sel
Fl-ac complementary - Coca, Sil
Fl-ac is followed by this remedy in diabetes - Ph-ac
Fl-ac is followed by this remedy in hip disease - Kali-c
Fl-ac is followed by this remedy in goitre - Spong
Cor-r complementary – Sulph (Boericke)
Graph complementary - Caust, Hep, Lyc (Ars, Tub, Arg-n (stomach) – Boericke)
Graph followed by - Sulph in skin, Sep in leucorrhoea, Calc in obesity in young females
Hep is followed by - Iod
Remedy follows bell in deafness after apoplexy - Hyos
Hyos follows this remedy in lasciviousness - Phos
Ign incompatible - Coff, Nux-v, Tab
Iod complementary - Lyc, (Badiaga - Boericke
Iod followed by this remedy in croup - Kali-bi
Ip complementary - Cupr (Arn – Boericke)
Cupr complementary – Calc (Boericke)
Ip is followed by this remedy in influenza - Ars
Kali-bi follows this remedy in dysentery when the scrapings have been removed - Canth or Carb-ac
Kali-bi followed by this remedy in skin and catarrhal conditions - Ant-t
Kali-br is followed by this remedy in Acne - Eug-j
Kali-c follows well after these remedies in loose rattling cough - Kali-s, Phos, Stann
Kali-c follows well after this remedy in stomach and bladder troubles - Nux-v
Nit-ac most effective after - Kali-c
Will bring on the menses when Nat-m fails to bring on the menses though apparently well indicated - Kali-c

Carb-an complementary - Calc-p
Ruta complementary - Calc-p (Boericke)
Bac complementary - Calc-p, Kali-c (Boericke)
Caul incompatible - Coff (Boericke)
Caust complementary - Carb-v, Petros, (Sulph - Nash "Leaders")
Cham complementary - Bell, Mag-c (Boericke)
Chronic of Cham (Guernsey) – Sanic (Clarke)
Rheum complementary - Mag-c
Kalmia complementary – Benz-ac (Boericke)
Chel complementary – Lyc, Bry (Boericke)
These remedies will be needed to complete the cure by Chel - Ars, Lyc, Sulph
Dros is followed by this remedy in pertussis - Cina
When Cina seem indicated in worm affections but fails - Santonine
Remedy cures dropsy after Apis and Apoc fail - Colch
Remedy to complete the curative work of Lach - Crot-c (Boericke)
Lach complementary - Hep, Lyc, Nit-ac (Salamand - Boericke)
Lach inimical - Acet-ac, Carb-ac, Amm-c, Sep
Like Nux-v in drunkenness in corpulent people with light hair, blue /grey eyes, florid complexion - Lob

Lyc complementary - Iod (Chel, Graph, Lach – Boericke)
Should not be used immediately before Lyc - Sulph (Kent)
Lyc acts with special benefit after – Calc & Sulph (Boericke)
Merc complementary - Bad (Boericke)
Follows well after Sep in bearing down - Nat-c
Nat-s complementary - Ars, Thuj (Boericke)
Kreos complementary in malignant diseases – Ars, Phos, Sulph (Boericke)
Kreos inimical – Carb-v (Boericke)
This remedy follows after Nit-ac has failed in enuresis - Benz-ac
When Rhus-t seems indicated but fails to relieve in chronic urticaria - Bov
Carb-v complementary – Kali-c, Dros (Boericke)
Brom follows this remedy in hard goiter - Iod
Brom follows in croup - Iod, Phos, Hep, Spong (especially in relapses after Iod)
When Bry fails - Upas (Boericke)
Bufo complementary in epilepsy - Salamand (Clarke)
Calad complementary - Nit-ac (Clarke)
Nux-v complementary – Sulph, Sep (Boericke)
Zinc inimical – Nux-v, Cham

Bowel Nosodes – keywords & relationship
Morgan pure(congestion) – Sulph
Morgan gaertner – Lyco
Proteus(CNS symptoms) – Nat-m
Mutable (alternation of symptoms) – Puls
Bacillus 7 (Mental & Physical fatigue)- Iodum / Kali-c
Gaertner (Malnutrition) – Phos / Sil
Dysentry co (Nervous tension/Anticipation) – Ars alb
Sycotic co (Irritability of mucosa / synovium) – Thuja
Faecalis - Sepia

Differential modalities
Chilly Patient
Coryza > open air – Nux-v, Cycl
Head > cold – Phos, Ars, Lac-d, Bar-c, Cycl
Dyspnoea >cold – Am-c
Cough > open air – Mag-p
Hot Patient
Headache > warm room – Sulph
Cough < cold air – All-c