Patients who are hospitalized or have surgery for benign prostatic hyperplasia (BPH) appear to be at higher risk for developing prostate cancer, researchers said here.
In a study utilizing a large Danish database, the overall risk of prostate cancer was 2.2-fold higher (Hazard ratio 2.22, 95% CI 2.13 to 2.31) if a man was hospitalized for symptoms of BPH, said Stig Bojesen, MD, of Copenhagen University Hospital, Herlev, Denmark.
The study was presented at the European Multidisciplinary Cancer Conference, formerly known as the Congress of the European Cancer Organization and Congress of the European Society for Medical Oncology (ECCO-ESMO).
Bojesen tapped into the national health database in Denmark to determine the relationship between BPH and prostate cancer. The researchers included in their study all men listed from 1980 to 2006, finding 187,591 men who were hospitalized for BPH and compared their risk of prostate cancer with 2,770,300 men in the general population.
“We found there was also a doubling of the risk of prostate cancer death in men who were hospitalized for [BPH],” he said at a press briefing. “We found that if the men underwent surgery for [BPH], the risk of prostate cancer death was increased nearly 8 times that of the general population.”
Among the men who were hospitalized for BPH in the Denmark database, 16,212 men later developed prostate cancer. Of the general population controls, 35,139 people later developed prostate cancer, Bojesen reported.
“About 70% of all men over age 70 have [BPH],” he said. “We do see an association, but we don’t know if it is causal. There might be some other explanation. It might be that both conditions – [BPH] and prostate cancer – might be stimulated by a third factor.”
Source : http://www.medpagetoday.com