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Date posted: June 6, 2012

Dr A B Ram Jyothis 

Abstract
Background: For almost a hundred years homeopaths have attempted to demonstrate the existence of the “potency effect” scientifically. The general implication of all this work is that highly dilute solutions (Homoeopathic potencies) do have effects that can be demonstrated in carefully controlled laboratory experiments. The present study aims to evaluate the effects of high potency in experimental animal and to evaluate the effects of 3x, 30c and 0/3 potencies of Matricaria Chamomilla on Central Nervous System.

Methods: The blind screening methodologies, well known in modern Psycho- Neuro pharmacology (Acto- photometer, Rota – rod apparatus, Eddy’s Hot plate, Maximal – electro shock method) were utilized for Central Nervous System action investigations.

Results: The results were statistically processed by Analysis of variance test (ANOVA) to compare the effects on treatment groups before and after treatment with control group and Dunnet’s t test were used to determine the effect of each treatment against control group. The results shows that Matricaria chamomilla 0/3, significantly reduce locomotor activity, exhibit muscle relaxant activity, causing analgesia and shows anti-convulsant activity than Matricaria chamomilla 3x and Matricaria chamomilla 30c.

Conclusion: This experimental study, revealed that high dilution when get dynamised by the process of succussion can have a significant effect on biological system. The central nervous system depression is significantly performed by 0/3 potencies than 3x and 30c.   

(Keywords – Matricaria chamomilla, C.N.S stimulant/depressant activity, muscle relaxant activity, Analgesic activity, Anti convulsant activity)

Introduction
The purpose of fundamental research is to describe and possibly to understand the phenomena purported by homoeopathy, using the experimental method. Experimental method is based on the assumption that any hypothesis should be testable, i. e. measurements can be done to prove or disprove it. To do this, we need specific and carefully selected experimental models.

Similar to clinical study, laboratory research is able to show biological activity of homeopathic remedies that cannot be explained as a placebo response. Laboratory research is also capable of shedding some new light on how the homeopathic remedies may work.  This study intended to verify the effect of Matricaria Chamomilla in various potencies on central nervous system of experimental animal and it may help to understand the biological phenomenon of the high potencies.

Aims and Objectives

  1. To evaluate the effects of high potency in Experimental Animal.
  2. To evaluate the effects of 3x, 30c and 0/3 potencies of Matricaria  chamomilla on Central nervous system. 

Materials:
Plant: Matricaria chamomilla

The Plant, Matricaria chamomilla was collected from Ooty under the supervision of Dr.D.Suresh Baburaj, Survey Officer, Medicinal plants survey and collection unit, Central Council for Research in Homoeopathy, Ooty, India. The mother tincture of Matricaria chamomilla was extracted as per the directions given in Homoeopathic Pharmacopoeia of India (Vol- 5, 1986)1. The 3x and 30c potency of Matricaria chamomilla were prepared with acqua distillata and 0/3 potency of Matricaria chamomilla brought from a reputed firm, which were used in this experiment.

Animals:
Male albino mice (Swiss strain) were procured from Sri Venkateswara Enterprises, Bangalore, India and bred in the animal house of Vinayaka Mission’s College of Pharmacy, Salem, India. They were fed on commercial diet and water adlibitum during the experiments. The pellet food containing 22.5% protein, 72.55% carbohydrate, 5% fat and sufficient vitamins and minerals. The cages were placed in well-ventilated place in the laboratory and were provided with 1.5 inches rice-bran bedding which was changed every day. The room temperature was maintained at 25+ 1oc . The animals were selected randomly. The study was approved by Institutional Animal Ethical Committee of Vinayaka Mission’s college of pharmacy, Salem, South India. Five groups (I-V), each comprising of six animals weighing between (20-25g) were selected.

Conclusion
In conclusion, the homoeopathic remedy, characterized by infinitesimal doses and by dynamization according to Hahnemann’s preparation technique has a marked informational character. The possibility of storing information from molecules can be used for therapeutical as well as experimental purpose.

The result of the study justify the opportunity of future researches concerning the intimate mechanism of inhibitory action on central nervous system of Chamomilla homoeopathic potencies in accordance with principle of similia.

References

  1. Chamomilla, Homoeopathic Pharmacopoeia of India, Vol- 5, Controller of publications, Government of India, 1986, pp 22.
  2. D’Amour, F.E and Smith, D.L; J. Pharm.Exptl. Therap.  1941, 72: 74
  3. Kulkarni,S.K; Life Sciences, 1980, 27 : 185 – 188
  4. Eddy, N.B. and Leimbach, D. J; J. Pharmacol. Exptl. Therap. 1953, 107: 385
  5. Dewis, P.B; Brit. J. Pharmac. Chemotherap.1953, 8 : 46
  6. Kulkarni, S.K and Dandiya, P.C; Indian J. Med. Res.1975, 63: 462-468
  7. Misra, A.K; Dandiya, P.C and Kulkarni, S.K; Indian J. Pharmac. 1973, 5 : 449-450
  8. Kulkarni, S.K; Arch. Int. Pharmacodyn. 1981, 252 : 124-132
  9. Hahnemann. S. ‘Materia Medica Pura’ Vol-1, reprint edition 1992, B.Jain publishers Pvt.Ltd, pp.379-381
  10. Guillemain, J. (1983) La recherché pharmacologique appliqué a I’Homeopathie, sa grandeur, ses faiblesses, Homeop.Fr 71, pp.191 – 200.
  11. Cristea A., Teodorescu – Negres.S, Darie.V et al  “ Chamomilla Homoeopathic Dilution effect on Central Nervous System – An Experimental pharmacological study”, Europ. Neuropsychopharmacol.3, pp.  446 – 447.
  12. Richard Hughes ‘A manual of pharmaco – dynamics’ 6 th reprint edition 2001, B.Jain publishers Pvt.Ltd, pp. 382

Dr.A.B.Ram Jyothis.M.D (Hom)
Department of Pharmacy
Fr.Muller Homeopathic Medical College. Mangalore
Email : pharmakon@rediffmail.com

Download full paper : www.similima.com/pdf/analgesic-activity-chamomilla.pdf

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